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  • a genetic enzyme deficiency called glucose-6-phosphate dehydrogenase (G6PD) deficiency;
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  • long QT syndrome;
  • an electrolyte imbalance (such as low levels of potassium or magnesium in your blood);
  • a personal or family history of becoming ill after eating fava beans; or
  • if you are of a certain ethnic background (Southern Europe, Mediterranean, Middle Eastern, African, Southeast Asian, Oceanic).

Primaquine can harm an unborn baby. Use effective birth control to prevent pregnancy while you are using primaquine, whether you are a man or a woman. Men should use condoms. Primaquine use by either parent may cause birth defects.
If you are a woman, keep using birth control after you stop taking primaquine, until you have at least one menstrual period. If you are a man, keep using condoms for at least 3 months after your last dose. Tell your doctor right away if a pregnancy occurs while either the mother or the father is using primaquine.

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